Failure to remove proteinaceous cohesion, topological catenations, or to complete DNA replication by mitosis in the budding yeast S. cerevisiae causes sister chromatid nondisjunction and the formation ...

Cleavage of cohesins and cyclin-dependent kinase (CDK) inhibition are thought to be sufficient for triggering chromosome segregation. Here we identify an essential requirement for anaphase chromosome ...

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...