Single-molecule imaging shows that three CBX2 protein molecules can seed Polycomb condensates that silence genes in stem cells. The discovery reveals how rare proteins organize genome regulation and ...

Stem cell-derived endothelial cell differentiation represents a rapidly advancing field that leverages the plasticity of pluripotent cells to generate functional vascular components. Central to the ...

T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs ...

MIAMI, FLORIDA (AUG. 7, 2025) – Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing ...

There is a high unmet need for accessible, affordable, and high-quality fertility care, as approximately 1 in 6 people are affected by infertility worldwide. While meiotic failure is a major cause of ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and potential therapeutic targets. The team used their reference map for normal ...

The mechanism for muscle stem cells repair could inspire therapeutics for muscle loss caused by injury, aging and weight-loss medications.

Two of them were responsible for overexpression in the cellular differentiation process, while one was responsible for inhibition. The finding could be used to study and potentially reverse the spread ...

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a transcriptional complex with β-catenin in human dental pulp stem cells, activating ...