Whenever cells divide, there is a high risk of damage to the genetic material. After all, the cell has to duplicate its entire genetic material and copy billions of genetic letters before it divides.

A research team from the University of California (UC), Irvine, has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. The ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the development ...

A research team has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery deepens the understanding of a new type of ...

U.S. Fast Track designation of ART6043 underpinned by promising clinical data to date and high unmet need in gBRCA-mutated ...

Antisense oligonucleotides (ASOs), used to treat genetic diseases, can affect how cells repair damage to their DNA. This is ...

Research from scientists at Albert Einstein College of Medicine, Northwestern University, and elsewhere indicates that forming long-term memories requires DNA damage and brain inflammation. The ...