RIT biomedical engineering researchers identify a protein that can reduce fibrosis and slow disease progression.

Heparanase, the sole mammalian enzyme capable of cleaving heparan sulphate chains, is emerging as a central regulator of extracellular matrix (ECM) dynamics. By reshaping the ECM and modifying the ...

Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a specialized population of neutrophils in the skin that produce extracellular matrix components, helping ...

Growing from a single cell into a complex organism with specialized tissues and organs requires a complex and coordinated process. But the mechanical signals that guide tissue and organ ...

Researchers developed a high-resolution spatial proteomics method to map protein and sugar changes in the brain. The study ...

Amyotrophic lateral sclerosis and frontotemporal dementia are heterogeneous diseases that are difficult to fully model in mice. One of the more common forms is caused by hexanucleotide repeat ...

In cell and animal models of amyotrophic lateral sclerosis (ALS), the expression of toxic dipeptides in neurons led to changes in the extracellular matrix (ECM) as a protective response. The authors ...

What Is an Extracellular Vesicle? Extracellular vesicles are membrane-bound organelles that are extruded from tissues containing different types of molecular cargo (e.g., RNA, protein, and metabolites ...

Cartilage injuries are a common clinical issue, often caused by trauma, severe infections, or degenerative joint diseases. The lack of direct blood supply to cartilage and limited access to nutrients ...

Senescence. It’s a beautiful-sounding word whose tones suggest it should be a perfume or an essential oil. But that’s not even close. Senescence is the loss of a cell’s power to divide and grow, thus ...