Lysosomes were once viewed mainly as cellular waste disposers, but are now recognized as key hubs for nutrient sensing and ...

What do cells do when they are “hungry”? Eukaryotic cells cope with starving conditions by eating their own components, a process called autophagy. Aa Aa Aa Normally, when you are hungry you look for ...

Researchers have discovered that lysosomes, traditionally viewed as cellular waste bins, sense mechanical forces and ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...

When the cell's recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and damaging the cell. Now, researchers at Umeå University have revealed the ...

Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash ...

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes. An organelle is a small structure in a cell that is ...

Both presenilin-1 or the less-studied presenilin-2 can act as the catalytic subunit of γ-secretase, the enzyme responsible for churning out Aβ peptides. A new study, published November 29 in Nature ...

The rap sheet for β-CTF is growing longer. The C-terminal fragment, produced when β-secretase cleaves APP, binds to—and blocks assembly of—vacuolar ATPase, a proton pump that fuels acidification of ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...