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Q&A: A generative AI technique for designing RNA with improved function

Ribonucleic acid, also called RNA, is a molecule present in all living cells. It plays a critical role in transmitting genetic instructions from DNA and creating proteins. With the power to execute a ...

Binding to RNA is not enough—changing its shape is what makes a drug work, study reveals

Ribonucleic acids (RNAs) serve as messengers between DNA and protein production, and perform a wide variety of regulatory functions across different cellular processes. This makes them an interesting ...
Nanowerk

Inosine (I) in RNA Structure and Function: A Versatile Nucleoside

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...
Nature

RNA function follows form – why is it so hard to predict?

At a virtual conference in November 2020, the winner of a biennial protein-structure-prediction challenge was announced: AlphaFold. Created by Google DeepMind, this computational tool had blown its ...
EurekAlert!

The function of 4.5SH RNA could be exploited for gene therapy (IMAGE)

In mice, 4.5SH RNA acts as a natural gene therapy agent, preventing the inclusion of mutations in RNA (left). By engineering recombinant 4.5SH RNA, it may be possible to apply this system to treat ...