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Muscle cramps A muscle cramp is a sudden, unexpected tightening of one or more muscles. Sometimes called a charley horse, a muscle cramp can be very painful. Exercising or working hard, especially in heat, can lead to muscle cramps. Some medicines and illnesses also might cause muscle cramps. Muscle cramps aren't usually harmful. Self-care measures can treat most muscle cramps. Symptoms Muscle cramps occur mostly in leg muscles, most often in the calf. Cramps usually last for seconds to minutes.
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